Richard J Cenedella Selected Research

Cataract (Cataracts)

6/2009	Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes.
8/2005	Concentration and distribution of ubiquinone (coenzyme Q), the endogenous lipid antioxidant, in the rat lens: effect of treatment with simvastatin.
6/2005	Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis.
7/2004	Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor.
1/2003	Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats.

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Richard J Cenedella Research Topics

Disease

5	Cataract (Cataracts) 06/2009 - 01/2003
2	Neoplasms (Cancer) 06/2009 - 01/2004
1	Alzheimer Disease (Alzheimer's Disease) 06/2009
1	Infections 06/2009
1	Stomach Neoplasms (Stomach Cancer) 06/2009
1	Absence Epilepsy (Childhood Absence Epilepsy) 06/2009
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 06/2009
1	Atherosclerosis 06/2009
1	Epilepsy (Aura) 06/2005
1	Niemann-Pick Diseases (Niemann Pick Disease) 06/2005

Drug/Important Bio-Agent (IBA)

3	3- beta- (2- (diethylamino)ethoxy)androst- 5- en- 17- oneIBA 06/2009 - 07/2004
2	Simvastatin (Zocor)FDA LinkGeneric 08/2005 - 01/2003
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 06/2009
1	PrionsIBA 06/2009
1	LipidsIBA 06/2009
1	Orlistat (Xenical)FDA Link 06/2009
1	Anti-Obesity Agents (Antiobesity Drugs)IBA 06/2009
1	AminesIBA 06/2005
1	lanosterol synthaseIBA 07/2004
1	Pharmaceutical PreparationsIBA 07/2004
1	CholesterolIBA 07/2004
1	PhosphotyrosineIBA 01/2004
1	Caveolin 1IBA 01/2004
1	Epidermal Growth Factor (EGF)IBA 01/2004
1	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 01/2003
1	simvastatin acidIBA 01/2003
1	EnzymesIBA 01/2003
1	isopreneIBA 01/2003
1	Proteins (Proteins, Gene)FDA Link 01/2003
1	SterolsIBA 01/2003

Therapy/Procedure

1	Lenses 01/2003